Don't route any of the wiring harness near ignition wires, the alternator or the charging circuit. The system is very sensitive to RFI/EMI. ( radio frequency interference electromagnetic interference)
If you are using a regular magnetic pickup distributor instead of the Holley dual sync distributor, make sure you use a shielded twisted pair cable connected as close to the pickup as possible. Cut the leads as close to the pickup as possible and still be able to make the splice. Slide the stainless braid back far enough so that when you slide it back out over the splice, it covers right up to the pickup. Run the shielded cable away from the distributor, coil, plug wires alternator etc to the ECM and ground the braided shield at that end, preferably to the same ground as the ECM.
This will give you a cleaner tach signal which is critical to make it run properly especially at idle.
When I did my 493 years ago the magnetic pickup wires inside the distributor were picking up so much RFI from the rotor arcing to the towers that instead of the tach signal trace on the data log being a single line like a pencil, it was about a 1/2 inch wide or more which equaled about 3000 rpm. The ECM didn't know whether to **** or steal second. Running an MSD box makes it even worse because of the multi strike. Even shielding the cable right up against the pickup didn't clean it up 100% but it was only about 25 rpm wide instead of 3000 and it behaved properly.
Kevin