In TX, the vent windows were typically closed as more cars were ordered with factory a/c, or in the '60s, had "hang-down" a/c installed later.
On our '66 Newport, the vent window seal seems to have a high level of silicone in it, rather than just rubber (as other brands tended to use). There always seems to be a small whistle in the area where the glass seals near the upper pivot point. Not a lot that can be done there, from what I remember from back then. With a power unit, you're at the mercy at the strength of the motor to get the glass fully seated. But with the manual system, cranking it "tight" past a certain point would result in additional wear on the closing mechanism with NO decrease in the whistle.
IF the seal is actually split, probably not a lot that can be done. Might try bridging the gap with some black silicone sealer (the glossier one rather than the more charcoal colored ones). Key thing would be getting it to stick to the existing seal.
A NOS seal might be found, BUT if it's not been in its wrapper "flat", it might take some doing to get it flattened back out for a better replacement outcome.
ALSO, check the slide at the front of the door glass for the existence of the flocking on the plastic base material of the slide. A neat design, but probably not the best for a really tight seal against wind noise. Especially on a hardtop. Plus, the little rubber cap at the top of the side window slide, too, as a potential wind whistle location, where some black silicone "in the gaps" might help quieten that area, too.
Just some thoughts,
CBODY67