Way back when the cars were new and used, there were no really beneficial additives other than some snake oil. Berrymans B-12 (the Berrymans DID work) and was what the local mechanics used exclusively, but the absolute BEST way to de-carbon an engine was to fill it up with good fuel and DRIVE it. I thought our '66 Newport 2bbl ran good, but each time I did a 400+ miles round trip home and back to school each month, it did run just a bit better after each trip. BTAIM
Back then, too, when Gulf Oil was still intact, they had a fuel additive named "Tri-Ad". It was a great fuel system/carb innards cleaner. Worked great and quick, but it disappeared along about the time that unleaded fuel appeared on the scene.
Some would get a Coke bottle, fill it with water and atf, 50-50, and drizzle it into the carb, keeping the engine running during all of that. Sounded like a rod was going to come of the side, but didn't. On seriously-carboned engines, it would make a difference. Then they'd add a bottle of B-12 to the gas and maybe use a spray can of B-12 to spray down the carb and the venturis.
Berryman's B-12 was around before the mid-1960s and I know it works. Basically a type of lacquer thinner, I suspect, but only have heard of Seafoam in the past few years. FWIW
Modern fuels have MUCH more detergents and cleanliness additives, to meet various OEM specs, that is isn't funny. So, comparatively, nothing should be needed in normal use. Look for "Tier 1" fuel labels on the gas pumps.
As to cleanliness/clean-up additives, there are some videos on such in the "Chris Fix" YouTube channel. He uses a borescope to investigate the tops of the piston tops, before and after, for several popular fuel treatments.
Many times, people will perceive they need to clean things up. They'll buy a popular fuel additive, put it in, and then nothing changes. Which means the additive was not really needed, not that it did not work, it seems to me. I've used one of the name brand fuel cleaners and could not tell any difference after that tank of fuel was used. Your experiences might vary. Watch the Chris Fix YouTube videos, too.
Using some ethanol treatment might be considered, but do NOT let the car sit and the float bowl fuel evaporate (as one carb shop owner mentioned in another forum). Some Marvel Mystery Oil will work in gasoline, too, at recommended dosages. Just not for valve seat issues.
Just some thoughts and observations,
CBODY67